Spatiotemporal Metabolic Atlas of Mammalian Organogenesis

Preface

Mammalian organogenesis is a complex phase where cells transform into functional organs through coordinated events like proliferation, differentiation, and migration. This spatiotemporal process is orchestrated by intricate transcriptional networks that determine cell identity, alongside metabolic pathways that provide essential energy and signaling molecules. These metabolic processes dynamically adapt to developmental demands, influencing cell fate and tissue architecture. Despite advances, the precise interplay between transcriptional regulation and metabolic reprogramming remains largely enigmatic. Critical questions persist regarding how metabolic flux feeds back into transcriptional control and how spatial metabolite gradients drive organ formation.

GitHub repository: https://github.com/jinyancool/embryo_paper/
Project homepage: https://jhuanglab.github.io/embryo/
Project interactive: https://jhuanglab2025.shinyapps.io/embryo/